Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications
Identifieur interne : 001931 ( Main/Exploration ); précédent : 001930; suivant : 001932Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications
Auteurs : Francesca Cicchetti [Canada] ; Denis Soulet [Canada] ; Thomas B. Freeman [États-Unis]Source :
- Brain [ 0006-8950 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Cell therapy offers the possibility of replacing degenerated neurons thereby improving the symptoms of neurodegenerative disorders such as Huntington's disease. However, clinical benefits in patients with Huntington's disease, if any, have been transient and modest. Grafts survived well at 18 months in one patient with Huntington's disease, but graft survival was markedly attenuated by 10 years in three other patients from this transplantation cohort. It is critical to delineate the causes of graft degeneration if such therapies will be utilized in patients with a goal of achieving meaningful clinical benefit. Similar challenges may also accrue to future stem cell therapies. Here we discuss the potential causes of suboptimal long-term graft survival in patients with Huntington's disease, including allograft immunoreactivity, microglial responses targeted to grafted cells and cell-to-cell neurotoxicity. We also discuss similar challenges and unique differences comparing neuronal grafts in patients with Parkinson's and Huntington's diseases.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000341
- to stream PascalFrancis, to step Curation: 000922
- to stream PascalFrancis, to step Checkpoint: 000248
- to stream Main, to step Merge: 001A23
- to stream Main, to step Curation: 001931
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications</title><author><name sortKey="Cicchetti, Francesca" sort="Cicchetti, Francesca" uniqKey="Cicchetti F" first="Francesca" last="Cicchetti">Francesca Cicchetti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche du CHUL (CHUQ), 2705, Boulevard Laurier</s1><s2>Québec, QC, G1V 4G2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec, QC, G1V 4G2</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Département de Psychiatrie et Neurosciences, Université Laval</s1><s2>Quebec, QC, G1K 7P4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Quebec, QC, G1K 7P4</wicri:noRegion></affiliation></author><author><name sortKey="Soulet, Denis" sort="Soulet, Denis" uniqKey="Soulet D" first="Denis" last="Soulet">Denis Soulet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche du CHUL (CHUQ), 2705, Boulevard Laurier</s1><s2>Québec, QC, G1V 4G2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec, QC, G1V 4G2</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Département de Psychiatrie et Neurosciences, Université Laval</s1><s2>Quebec, QC, G1K 7P4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Quebec, QC, G1K 7P4</wicri:noRegion></affiliation></author><author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurosurgery and Brain Repair, University of South Florida, 2 Tampa General Circle, 7th Floor</s1><s2>Tampa, FL, 33606-3571</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Tampa, FL, 33606-3571</wicri:noRegion><orgName type="university">Université de Floride du Sud</orgName><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Center of Excellence for Aging and Brain Repair, University of South Florida, 2 Tampa General Circle, 7th Floor</s1><s2>Tampa, FL, 33606-3571</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Tampa, FL, 33606-3571</wicri:noRegion><orgName type="university">Université de Floride du Sud</orgName><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0151134</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0151134 INIST</idno><idno type="RBID">Pascal:11-0151134</idno><idno type="wicri:Area/PascalFrancis/Corpus">000341</idno><idno type="wicri:Area/PascalFrancis/Curation">000922</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000248</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000248</idno><idno type="wicri:doubleKey">0006-8950:2011:Cicchetti F:neuronal:degeneration:in</idno><idno type="wicri:Area/Main/Merge">001A23</idno><idno type="wicri:Area/Main/Curation">001931</idno><idno type="wicri:Area/Main/Exploration">001931</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications</title><author><name sortKey="Cicchetti, Francesca" sort="Cicchetti, Francesca" uniqKey="Cicchetti F" first="Francesca" last="Cicchetti">Francesca Cicchetti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche du CHUL (CHUQ), 2705, Boulevard Laurier</s1><s2>Québec, QC, G1V 4G2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec, QC, G1V 4G2</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Département de Psychiatrie et Neurosciences, Université Laval</s1><s2>Quebec, QC, G1K 7P4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Quebec, QC, G1K 7P4</wicri:noRegion></affiliation></author><author><name sortKey="Soulet, Denis" sort="Soulet, Denis" uniqKey="Soulet D" first="Denis" last="Soulet">Denis Soulet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre de Recherche du CHUL (CHUQ), 2705, Boulevard Laurier</s1><s2>Québec, QC, G1V 4G2</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec, QC, G1V 4G2</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Département de Psychiatrie et Neurosciences, Université Laval</s1><s2>Quebec, QC, G1K 7P4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Quebec, QC, G1K 7P4</wicri:noRegion></affiliation></author><author><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Neurosurgery and Brain Repair, University of South Florida, 2 Tampa General Circle, 7th Floor</s1><s2>Tampa, FL, 33606-3571</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Tampa, FL, 33606-3571</wicri:noRegion><orgName type="university">Université de Floride du Sud</orgName><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Center of Excellence for Aging and Brain Repair, University of South Florida, 2 Tampa General Circle, 7th Floor</s1><s2>Tampa, FL, 33606-3571</s2><s3>USA</s3><sZ>3 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Tampa, FL, 33606-3571</wicri:noRegion><orgName type="university">Université de Floride du Sud</orgName><placeName><settlement type="city">Tampa</settlement><region type="state">Floride</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Degeneration</term><term>Huntington disease</term><term>Nervous system diseases</term><term>Transplantation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dégénérescence</term><term>Chorée de Huntington</term><term>Pathologie du système nerveux</term><term>Transplantation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cell therapy offers the possibility of replacing degenerated neurons thereby improving the symptoms of neurodegenerative disorders such as Huntington's disease. However, clinical benefits in patients with Huntington's disease, if any, have been transient and modest. Grafts survived well at 18 months in one patient with Huntington's disease, but graft survival was markedly attenuated by 10 years in three other patients from this transplantation cohort. It is critical to delineate the causes of graft degeneration if such therapies will be utilized in patients with a goal of achieving meaningful clinical benefit. Similar challenges may also accrue to future stem cell therapies. Here we discuss the potential causes of suboptimal long-term graft survival in patients with Huntington's disease, including allograft immunoreactivity, microglial responses targeted to grafted cells and cell-to-cell neurotoxicity. We also discuss similar challenges and unique differences comparing neuronal grafts in patients with Parkinson's and Huntington's diseases.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Floride</li></region><settlement><li>Tampa</li></settlement><orgName><li>Université de Floride du Sud</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Cicchetti, Francesca" sort="Cicchetti, Francesca" uniqKey="Cicchetti F" first="Francesca" last="Cicchetti">Francesca Cicchetti</name></noRegion><name sortKey="Cicchetti, Francesca" sort="Cicchetti, Francesca" uniqKey="Cicchetti F" first="Francesca" last="Cicchetti">Francesca Cicchetti</name><name sortKey="Soulet, Denis" sort="Soulet, Denis" uniqKey="Soulet D" first="Denis" last="Soulet">Denis Soulet</name><name sortKey="Soulet, Denis" sort="Soulet, Denis" uniqKey="Soulet D" first="Denis" last="Soulet">Denis Soulet</name></country><country name="États-Unis"><region name="Floride"><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name></region><name sortKey="Freeman, Thomas B" sort="Freeman, Thomas B" uniqKey="Freeman T" first="Thomas B." last="Freeman">Thomas B. Freeman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001931 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001931 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:11-0151134
|texte= Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications
}}
| This area was generated with Dilib version V0.6.29. |  |